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Watch Intently (1)mitotane decreases levels of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Mitotane is a strong inducer of cytochrome P-4503A4; watch when coadministered with CYP3A4 substrates for feasible dosage changes.For those with delicate movement sickness heritage (which typically ensures that it d